2'-O-(tert-Butyldimethylsilyl)paclitaxel 7-O-triflate - CAS 165065-01-0

Catalog: BB055333
Product Name: 2'-O-(tert-Butyldimethylsilyl)paclitaxel 7-O-triflate
CAS: 165065-01-0
Synonyms: 2'-O-(tert-Butyldimethylsilyl)-7-O-(trifluoromethanesulfonyl)paclitaxel; (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-9-(((2R,3S)-3-Benzamido-2-((tert-butyldimethylsilyl)oxy)-3-phenylpropanoyl)oxy)-12-(benzoyloxy)-11-hydroxy-4a,8,13,13-tetramethyl-5-oxo-4-(((trifluoromethyl)sulfonyl)oxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-1H-7,11-methanocyclodeca[3,4]benzo[1,2-b]oxete-6,12b-diyl Diacetate; [2aR-[2aα,4β,4aβ,6β,9α(αR*,βS*),11α,12α,12aα,12bα]]-β-(Benzoylamino)-α-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-benzenepropanoic Acid 6,12b-bis(Acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-11-hydroxy-4a,8,13,13-tetramethyl-5-oxo-4-[[(trifluoromethyl)sulfonyl]oxy]-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl Ester
2'-O-(tert-Butyldimethylsilyl)paclitaxel 7-O-triflate

Technical Data

Computed Properties
IUPAC Name:[(1S,2S,3R,4S,7R,9S,10S,12R,15S)-4,12-diacetyloxy-15-[(2R,3S)-3-benzamido-2-[tert-butyl(dimethyl)silyl]oxy-3-phenylpropanoyl]oxy-1-hydroxy-10,14,17,17-tetramethyl-11-oxo-9-(trifluoromethylsulfonyloxy)-6-oxatetracyclo[11.3.1.03,10.04,7]heptadec-13-en-2-yl] benzoate
Description:2'-O-(tert-Butyldimethylsilyl)paclitaxel 7-O-triflate is an intermediate in the synthesis of 6α-Hydroxy Paclitaxel (H948890), the major human metabolite of Paclitaxel (P132500), an antineoplastic. Used in the study of structure and function of microtubles into tubulin. Paclitaxel is now used to treat patients with lung, ovarian, breast cancer, head and neck cancer, and advanced forms of Kaposi's sarcoma. Paclitaxel is a mitotic inhibitor used in cancer chemotherapy.
Molecular Weight:1100.23
Molecular Formula:C54H64F3NO16SSi
Canonical SMILES:CC1=C2C(C(=O)C3(C(CC4C(C3C(C(C2(C)C)(CC1OC(=O)C(C(C5=CC=CC=C5)NC(=O)C6=CC=CC=C6)O[Si](C)(C)C(C)(C)C)O)OC(=O)C7=CC=CC=C7)(CO4)OC(=O)C)OS(=O)(=O)C(F)(F)F)C)OC(=O)C
InChI:InChI=1S/C54H64F3NO16SSi/c1-30-36(70-48(64)42(74-76(10,11)49(4,5)6)40(33-21-15-12-16-22-33)58-46(62)34-23-17-13-18-24-34)28-53(65)45(71-47(63)35-25-19-14-20-26-35)43-51(9,44(61)41(69-31(2)59)39(30)50(53,7)8)37(73-75(66,67)54(55,56)57)27-38-52(43,29-68-38)72-32(3)60/h12-26,36-38,40-43,45,65H,27-29H2,1-11H3,(H,58,62)/t36-,37-,38+,40-,41+,42+,43-,45-,51+,52-,53+/m0/s1
InChI Key:HCWLKEZRCWJKHE-HYWITDEOSA-N
References:Walle, T., et al. Biochem. Pharm., 46, 1661 (1993); Kumar, G., et al. Drug Metab. Dispos., 22, 177 (1994); Letourneau, P.C., et al. J. Cell Biol., 98, 1355 (1984); Manfredi, J.J., et al. Pharmacol. Ther., 25, 83 (1984), Danesi, R., et al. Mol. Pharmacol., 47, 1106 (1995); Markman, M., et al. Expert. Opin. Pharmacother., 3, 755 (2002); Stone, G.W., et al. N. Engl. J. Med., 350, 221 (2004).

Related Products

Online Inquiry
Verification code

Customer Support

If the product you need is not in our catalog, please contact us in time to submit your needs. You can help our website get better and better. Why not submit the request today?

Submit Requirement

Customer Centered

Global Delivery

Global Delivery

Warehouses in multiple cities to ensure fast delivery
Quality Assurance

Quality Assurance

Strict process parameter control to ensure product quality
Large Stock

Large Stock

> 20,000 building blocks and intermediates from stock
Process Scale-up

Process Scale-up

Process scale-up from lab to industrial scale
Flexible Batch Size

Flexible Batch Size

Flexible batch size for diverse industrial demands

Related Functional Groups

Other Building Blocks

Customers Also Viewed

INDUSTRY LEADERS TRUST OUR PRODUCTS

Phone

US & Canada (Toll free):

UK:

International:

E-mail & Fax

E-mail:

Fax:

 

Address

USA:

UK:

BOC Sciences

Copyright © 2024 BOC Sciences. All rights reserved.

Our Products

Amines and Anilines

Carbonyl Compounds

Nitrogen Compounds

Sulfur Compounds

Other Building Blocks

Fluorinated Building Blocks

Alcohols and Derivatives

Boronic Acids and Esters

Phosphorus Compounds

Oxygen Compounds

Heterocyclic Building Blocks

Allenes

Halides

Alkanes

Alkenes

Alkynes

Arenes

Inquiry Basket
Loading ......
Delete selectedGo to checkout