2'-O-Methyluridine - CAS 2140-76-3

Catalog:	BB016822
Product Name:	2'-O-Methyluridine
CAS:	2140-76-3
Synonyms:	2'-(O-Methyl) Uridine; Uridine, 2'-O-methyl-; O(2')-Methyluridine; 1-((2R,3R,4R,5R)-4-hydroxy-5-(hydroxymethyl)-3-methoxytetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione; 1-(2-O-Methyl-β-D-ribofuranosyl)uracil

Catalog	Size	Price	Stock	Quantity
BB016822	25 g	$239	In stock

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Technical Data

IUPAC Name:	1-[(2R,3R,4R,5R)-4-hydroxy-5-(hydroxymethyl)-3-methoxyoxolan-2-yl]pyrimidine-2,4-dione
Description:	Uridine analog. Used for preparation of antiviral nucleoside derivatives as inhibitors of subgenomic hepatitis C virus RNA replication.
Molecular Weight:	258.23
Molecular Formula:	C10H14N2O6
Canonical SMILES:	COC1C(C(OC1N2C=CC(=O)NC2=O)CO)O
InChI:	InChI=1S/C10H14N2O6/c1-17-8-7(15)5(4-13)18-9(8)12-3-2-6(14)11-10(12)16/h2-3,5,7-9,13,15H,4H2,1H3,(H,11,14,16)/t5-,7-,8-,9-/m1/s1
InChI Key:	SXUXMRMBWZCMEN-ZOQUXTDFSA-N
Melting Point:	154-156 °C
Purity:	≥95%
Density:	1.53±0.1 g/cm³ (Predicted)
Solubility:	Soluble in DMSO (Slightly), Methanol (Slightly)
Appearance:	White solid
Storage:	Store at 2-8 °C
LogP:	-2.19780

Publication Number	Title	Priority Date
CN-113151481-A	Application of biomarker in esophageal squamous carcinoma differentiation grade evaluation	20210413
WO-2020206509-A1	Multiplex detection of nucleic acids using mixed reporters	20200630
EP-3901260-A1	Coronavirus vaccine	20200422
EP-3901261-A1	Coronavirus vaccine	20200422
US-2021324383-A1	Microrna and inhibitors thereof and methods of treatment	20200416

PMID	Publication Date	Title	Journal
21051237	20101201	Synthesis, gene-silencing activity and nuclease resistance of 3'-3'-linked double short hairpin RNA	Bioorganic & medicinal chemistry
20836892	20100914	Transfer RNA modifications and genes for modifying enzymes in Arabidopsis thaliana	BMC plant biology
19835380	20091124	Chemical synthesis of LNA-2-thiouridine and its influence on stability and selectivity of oligonucleotide binding to RNA	Biochemistry
18189373	20080207	Effect of a water molecule on the sugar puckering of uridine, 2'-deoxyuridine, and 2'-O-methyl uridine inserted in duplexes	The journal of physical chemistry. A
17725606	20080201	Impaired expression of indoleamine 2, 3-dioxygenase in monocyte-derived dendritic cells in response to Toll-like receptor-7/8 ligands	Immunology

Complexity:	385
Compound Is Canonicalized:	Yes
Covalently-Bonded Unit Count:	1
Defined Atom Stereocenter Count:	4
Defined Bond Stereocenter Count:	0
Exact Mass:	258.08518617
Formal Charge:	0
Heavy Atom Count:	18
Hydrogen Bond Acceptor Count:	6
Hydrogen Bond Donor Count:	3
Isotope Atom Count:	0
Monoisotopic Mass:	258.08518617
Rotatable Bond Count:	3
Topological Polar Surface Area:	108
Undefined Atom Stereocenter Count:	0
Undefined Bond Stereocenter Count:	0
XLogP3:	-1.4