2-Methoxy-6-(piperazin-1-yl)pyrazine - CAS 89007-52-3
Catalog: |
BB060267 |
Product Name: |
2-Methoxy-6-(piperazin-1-yl)pyrazine |
CAS: |
89007-52-3 |
Synonyms: |
1-(6-Methoxypyrazin-2-yl)piperazine; 6'-Methoxy-3,4,5,6-tetrahydro-2H-[1,2']bipyrazinyl |
IUPAC Name: | 2-methoxy-6-piperazin-1-ylpyrazine |
Description: | 2-Methoxy-6-(piperazin-1-yl)pyrazine can be used as potential mGlu5 receptor modulators to treat and/or prevent psychiatric disorders associated with glutamate dysfunction such as schizophrenia or cognitive decline such as dementia or cognitive impairment. |
Molecular Weight: | 194.23 |
Molecular Formula: | C9H14N4O |
Canonical SMILES: | COC1=NC(=CN=C1)N2CCNCC2 |
InChI: | InChI=1S/C9H14N4O/c1-14-9-7-11-6-8(12-9)13-4-2-10-3-5-13/h6-7,10H,2-5H2,1H3 |
InChI Key: | VSARXIPDRASTTK-UHFFFAOYSA-N |
References: | Grauert, M., et.al. U.S. Pat. Appl. Publ., 218, (2013). |
GHS Hazard Statement: | H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral] |
Precautionary Statement: | P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P354+P338, P317, P319, P321, P330, P332+P317, P362+P364, P403+P233, P405, and P501 |
Signal Word: | Danger |
Publication Number | Title | Priority Date |
US-2013184248-A1 | Novel compounds | 20120117 |
US-8889677-B2 | Substituted triazoles useful as mGlu5 receptor modulators | 20120117 |
TW-200831080-A | Compounds and compositions as inhibitors of cannabinoid receptor 1 activity | 20061215 |
AU-2004263306-A1 | Piperazine with or-substituted phenyl group and their use as GLYT1 inhibitors | 20030811 |
AU-2004263306-B2 | Piperazine with or-substituted phenyl group and their use as GLYT1 inhibitors | 20030811 |
CA-2534675-A1 | Piperazine with or-substituted phenyl group and their use as glyt1 inhibitors | 20030811 |
CA-2534675-C | Piperazine with or-substituted phenyl group and their use as glyt1 inhibitors | 20030811 |
DE-602004011076-T2 | PIPERAZINE WITH OR-SUBSTITUTED PHENYL GROUP AND ITS USE AS GLYT1 INHIBITORS | 20030811 |
EA-009986-B1 | PIPERAZIN WITH OR-SUBSTITUTED PENYL GROUP AND ITS APPLICATION AS GLYT1 INHIBITORS | 20030811 |
EP-1656361-A1 | Piperazine with or-substituted phenyl group and their use as glyt1 inhibitors | 20030811 |
Complexity: | 172 |
Compound Is Canonicalized: | Yes |
Covalently-Bonded Unit Count: | 1 |
Defined Atom Stereocenter Count: | 0 |
Defined Bond Stereocenter Count: | 0 |
Exact Mass: | 194.11676108 |
Formal Charge: | 0 |
Heavy Atom Count: | 14 |
Hydrogen Bond Acceptor Count: | 5 |
Hydrogen Bond Donor Count: | 1 |
Isotope Atom Count: | 0 |
Monoisotopic Mass: | 194.11676108 |
Rotatable Bond Count: | 2 |
Topological Polar Surface Area: | 50.3Ų |
Undefined Atom Stereocenter Count: | 0 |
Undefined Bond Stereocenter Count: | 0 |
XLogP3: | -0.1 |
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