2-Fluoroethyl chloroformate - CAS 462-27-1

Catalog:	BB026103
Product Name:	2-Fluoroethyl chloroformate
CAS:	462-27-1
Synonyms:	2-fluoroethyl carbonochloridate

Technical Data

Safety and Hazards

Patents

Computed Properties

IUPAC Name:	2-fluoroethyl carbonochloridate
Description:	2-Fluoroethyl chloroformate (CAS# 462-27-1) is an intermediate used to prepare selective MMP-12 inhibitors for use in COPD treatment. It is also used in the synthesis of potent and selective nonpeptide antagonist of melanocortin-4 receptor.
Molecular Weight:	126.51
Molecular Formula:	C3H4ClFO2
Canonical SMILES:	C(CF)OC(=O)Cl
InChI:	InChI=1S/C3H4ClFO2/c4-3(6)7-2-1-5/h1-2H2
InChI Key:	FOHSVPIFZASOED-UHFFFAOYSA-N
Boiling Point:	115.5 ℃ at 760 mmHg
Density:	1.34 g/cm³
MDL:	MFCD01726287
LogP:	1.33130

Publication Number	Title	Priority Date
US-2020095250-A1	Pyrazolopyrimidine compounds and uses thereof	20180925
WO-2020068729-A1	Pyrazolo[4,3-d]pyrimidine compounds as alk2 abd/or fgfr modulators	20180925
TW-202028207-A	Pyrazolopyrimidine compounds and uses thereof	20180925
EP-3856348-A1	Pyrazolo[4,3-d]pyrimidine compounds as alk2 abd/or fgfr modulators	20180925
US-11111247-B2	Pyrazolopyrimidine compounds and uses thereof	20180925

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Related Functional Groups

Carbonyl Compounds

[91125-43-8]
Sulfophenyl nonanoate sodium salt
[5650-34-0]
Oxiran-2-yl(phenyl)methanone
[1035840-45-9]
1-(5-Methoxy-1,3-benzoxazol-2-yl)piperidine-3-carboxylic acid
[1006443-01-1]
1-(5-Nitropyridin-2-yl)-1H-pyrazole-3-carboxylic acid
[1016519-61-1]
2-(Methyl-2-pyridylamino)acetic Acid
[104496-91-5]
2-(Pyridin-2-ylthio)acetohydrazide

Fluorinated Building Blocks

[1006473-17-1]
[(2,3-Difluorophenyl)methyl][(1,3-dimethylpyrazol-4-yl)methyl]amine
[1106917-71-8]
[3-(Difluoromethoxy)phenyl]methanamine hydrochloride
[1866059-82-6]
1,1,2,2-Tetrafluoro-3-methylsulfonylpropane
[2367-82-0]
1,2,3,5-Tetrafluorobenzene
[1820736-42-2]
1-{4-[3-(Trifluoromethyl)-1H-pyrazol-1-yl]phenyl}methanamine hydrochloride
[479552-94-8]
1H-Pyrrolo[2,3-b]pyridin-4-yl trifluoromethanesulfonate

Other Pyrimidines

[452-76-6]
2,4-Difluorotoluene
[937601-34-8]
3-Bromo-2,5-dimethylpyrazolo[1,5-a]pyrimidine-7-carboxylic acid
[150517-77-4]
3-Fluoro-5-(trifluoromethyl)benzylamine
[832739-73-8]
4-(3,5-Dichlorophenyl)pyrimidine-2-thiol
[1489-53-8]
1,2,3-Trifluorobenzene
[45867-11-6]
2-Amino-5-chloro-4-pyrimidinecarboxylic acid

GHS Hazard Statement:	H226 (100%): Flammable liquid and vapor [Warning Flammable liquids]
Precautionary Statement:	P210, P233, P240, P241, P242, P243, P260, P261, P264, P271, P280, P301+P330+P331, P303+P361+P353, P304+P340, P305+P351+P338, P310, P311, P321, P363, P370+P378, P403+P233, P403+P235, P405, and P501
Signal Word:	Danger

Complexity:	66
Compound Is Canonicalized:	Yes
Covalently-Bonded Unit Count:	1
Defined Atom Stereocenter Count:	0
Defined Bond Stereocenter Count:	0
Exact Mass:	125.9883852
Formal Charge:	0
Heavy Atom Count:	7
Hydrogen Bond Acceptor Count:	3
Hydrogen Bond Donor Count:	0
Isotope Atom Count:	0
Monoisotopic Mass:	125.9883852
Rotatable Bond Count:	3
Topological Polar Surface Area:	26.3 Å²
Undefined Atom Stereocenter Count:	0
Undefined Bond Stereocenter Count:	0
XLogP3:	1.5