2-Chloro-5-nitropyridine - CAS 4548-45-2
Catalog: |
BB025890 |
Product Name: |
2-Chloro-5-nitropyridine |
CAS: |
4548-45-2 |
Synonyms: |
2-chloro-5-nitropyridine |
IUPAC Name: | 2-chloro-5-nitropyridine |
Description: | 2-Chloro-5-nitropyridine (CAS# 4548-45-2) is used in the synthesis of 4-(Benzoylaminophenoxy)phenol derivatives as androgen receptor antagonists. Also used in the preparation of novel VEGFR2 kinase inhibitors used in controlling angiogenesis. |
Molecular Weight: | 158.54 |
Molecular Formula: | C5H3ClN2O2 |
Canonical SMILES: | C1=CC(=NC=C1[N+](=O)[O-])Cl |
InChI: | InChI=1S/C5H3ClN2O2/c6-5-2-1-4(3-7-5)8(9)10/h1-3H |
InChI Key: | BAZVFQBTJPBRTJ-UHFFFAOYSA-N |
Boiling Point: | 256.6 °C at 760 mmHg |
Melting Point: | 106-110 °C |
Purity: | > 99.0 % (GC) |
Density: | 1.489 g/cm3 |
Appearance: | Crystalline powder |
Storage: | Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances. |
MDL: | MFCD00006240 |
LogP: | 2.16640 |
GHS Hazard Statement: | H302 (10.64%): Harmful if swallowed [Warning Acute toxicity, oral] |
Precautionary Statement: | P261, P264, P270, P271, P280, P301+P312, P302+P352, P304+P340, P305+P351+P338, P312, P321, P330, P332+P313, P337+P313, P362, P403+P233, P405, and P501 |
Signal Word: | Warning |
Publication Number | Title | Priority Date |
CN-113511980-A | Aromatic polyimide with main chain containing benzonorbornene structure and preparation method thereof | 20210710 |
CN-112209972-A | Large-steric-hindrance N-heterocyclic carbene-palladium complex, preparation method and application thereof, and synthetic method of sonchibu based on complex | 20201014 |
CN-112142654-A | Aromatic diamine monomer containing fluorene group and pyridine heterocyclic structure and preparation method and application thereof | 20200927 |
CN-112159524-A | Soluble polyimide film and preparation method and application thereof | 20200927 |
CN-111777549-A | Synthesis process of 2-methoxy-3-bromo-5-fluoropyridine | 20200707 |
PMID | Publication Date | Title | Journal |
22220084 | 20111101 | 2-(4-Methyl-phen-oxy)-5-nitro-pyridine | Acta crystallographica. Section E, Structure reports online |
22220086 | 20111101 | 2-(Naphthalen-2-yl-oxy)-5-nitro-pyridine | Acta crystallographica. Section E, Structure reports online |
21579084 | 20100402 | 2-Chloro-3-nitro-pyridine | Acta crystallographica. Section E, Structure reports online |
21580672 | 20100317 | 2-Chloro-5-nitro-pyridine | Acta crystallographica. Section E, Structure reports online |
17551199 | 20070601 | Ring opening of pyridines: the pseudo-cis and pseudo-trans isomers of tetra-n-butylammonium 4-nitro-5-oxo-2-pentenenitrilate | Acta crystallographica. Section C, Crystal structure communications |
Complexity: | 136 |
Compound Is Canonicalized: | Yes |
Covalently-Bonded Unit Count: | 1 |
Defined Atom Stereocenter Count: | 0 |
Defined Bond Stereocenter Count: | 0 |
Exact Mass: | 157.9883050 |
Formal Charge: | 0 |
Heavy Atom Count: | 10 |
Hydrogen Bond Acceptor Count: | 3 |
Hydrogen Bond Donor Count: | 0 |
Isotope Atom Count: | 0 |
Monoisotopic Mass: | 157.9883050 |
Rotatable Bond Count: | 0 |
Topological Polar Surface Area: | 58.7 Å2 |
Undefined Atom Stereocenter Count: | 0 |
Undefined Bond Stereocenter Count: | 0 |
XLogP3: | 2.2 |
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