2-Aminopurine - CAS 452-06-2
Catalog: |
BB025786 |
Product Name: |
2-Aminopurine |
CAS: |
452-06-2 |
Synonyms: |
7H-purin-2-amine; 7H-purin-2-amine |
IUPAC Name: | 7H-purin-2-amine |
Description: | 2-Aminopurine (CAS# 452-06-2) is a useful research chemical, a protein kinase inhibitor. 2-Aminopurine is also used in the monitoring and making of DNA nanodevices. |
Molecular Weight: | 135.13 |
Molecular Formula: | C5H5N5 |
Canonical SMILES: | C1=C2C(=NC(=N1)N)N=CN2 |
InChI: | InChI=1S/C5H5N5/c6-5-7-1-3-4(10-5)9-2-8-3/h1-2H,(H3,6,7,8,9,10) |
InChI Key: | MWBWWFOAEOYUST-UHFFFAOYSA-N |
Boiling Point: | 616.3 °C at 760 mmHg |
Density: | 1.612 g/cm3 |
Solubility: | >20.3 [ug/mL] (The mean of the results at pH 7.4) |
MDL: | MFCD00005566 |
LogP: | 0.51630 |
GHS Hazard Statement: | H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral] |
Precautionary Statement: | P264, P270, P301+P317, P330, and P501 |
Signal Word: | Warning |
Publication Number | Title | Priority Date |
WO-2021099838-A1 | Adenosine receptor antagonist compounds | 20191119 |
AU-2018364807-A1 | Purine based compounds as toll-like receptor 9 antagonist | 20171108 |
US-2020347062-A1 | Purine based compounds as toll-like receptor 9 antagonist | 20171108 |
AU-2018238079-A1 | Novel pyridone carboxylic acid derivative or salt thereof | 20170324 |
JP-WO2018174266-A1 | Novel pyridonecarboxylic acid derivative or salt thereof | 20170324 |
PMID | Publication Date | Title | Journal |
25739386 | 20150901 | Double Stranded RNA-Dependent Protein Kinase is Necessary for TNF-α-Induced Osteoclast Formation In Vitro and In Vivo | Journal of cellular biochemistry |
24150608 | 20140201 | Small-molecule inhibitors of PKR improve glucose homeostasis in obese diabetic mice | Diabetes |
23017353 | 20130201 | Dissolution testing and potentiometric determination of famciclovir in pure, dosage forms and biological fluids | Bioelectrochemistry (Amsterdam, Netherlands) |
23405061 | 20130101 | A critical role for MAPK signalling pathways in the transcriptional regulation of toll like receptors | PloS one |
23070860 | 20121105 | Synthesis and photophysical characterisation of a fluorescent nucleoside analogue that signals the presence of an abasic site in RNA | Chembiochem : a European journal of chemical biology |
Complexity: | 127 |
Compound Is Canonicalized: | Yes |
Covalently-Bonded Unit Count: | 1 |
Defined Atom Stereocenter Count: | 0 |
Defined Bond Stereocenter Count: | 0 |
Exact Mass: | 135.05449518 |
Formal Charge: | 0 |
Heavy Atom Count: | 10 |
Hydrogen Bond Acceptor Count: | 4 |
Hydrogen Bond Donor Count: | 2 |
Isotope Atom Count: | 0 |
Monoisotopic Mass: | 135.05449518 |
Rotatable Bond Count: | 0 |
Topological Polar Surface Area: | 80.5 |
Undefined Atom Stereocenter Count: | 0 |
Undefined Bond Stereocenter Count: | 0 |
XLogP3: | -0.2 |
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