2-amino-5-bromo-3-chloropyrazine - CAS 21943-13-5
Catalog: |
BB017214 |
Product Name: |
2-amino-5-bromo-3-chloropyrazine |
CAS: |
21943-13-5 |
Synonyms: |
5-bromo-3-chloro-2-pyrazinamine; 5-bromo-3-chloropyrazin-2-amine |
IUPAC Name: | 5-bromo-3-chloropyrazin-2-amine |
Description: | 2-amino-5-bromo-3-chloropyrazine (CAS# 21943-13-5) is a useful research chemical. |
Molecular Weight: | 208.44 |
Molecular Formula: | C4H3BrClN3 |
Canonical SMILES: | C1=C(N=C(C(=N1)N)Cl)Br |
InChI: | InChI=1S/C4H3BrClN3/c5-2-1-8-4(7)3(6)9-2/h1H,(H2,7,8) |
InChI Key: | RLBJPMURTWCBMZ-UHFFFAOYSA-N |
Boiling Point: | 271.288 °C at 760 mmHg |
Purity: | 97.0 % |
Density: | 1.961 g/cm3 |
LogP: | 2.05590 |
GHS Hazard Statement: | H301 (100%): Toxic if swallowed [Danger Acute toxicity, oral]; H318 (100%): Causes serious eye damage [Danger Serious eye damage/eye irritation] |
Precautionary Statement: | P264, P264+P265, P270, P280, P301+P316, P305+P354+P338, P317, P321, P330, P405, and P501 |
Signal Word: | Danger |
Publication Number | Title | Priority Date |
WO-2021032148-A1 | Aminopyrazine compounds as hpk1 inhibitor and the use thereof | 20190821 |
EP-3772513-A1 | Shp2 inhibitors | 20190809 |
WO-2021028362-A1 | Shp2 inhibitors | 20190809 |
WO-2021026099-A1 | Kif18a inhibitors | 20190802 |
WO-2020147739-A1 | Lysophosphatidic acid receptor antagonists and preparation method therefor | 20190115 |
PMID | Publication Date | Title | Journal |
20936789 | 20101111 | Aminopyrazine inhibitors binding to an unusual inactive conformation of the mitotic kinase Nek2: SAR and structural characterization | Journal of medicinal chemistry |
Complexity: | 102 |
Compound Is Canonicalized: | Yes |
Covalently-Bonded Unit Count: | 1 |
Defined Atom Stereocenter Count: | 0 |
Defined Bond Stereocenter Count: | 0 |
Exact Mass: | 206.91989 |
Formal Charge: | 0 |
Heavy Atom Count: | 9 |
Hydrogen Bond Acceptor Count: | 3 |
Hydrogen Bond Donor Count: | 1 |
Isotope Atom Count: | 0 |
Monoisotopic Mass: | 206.91989 |
Rotatable Bond Count: | 0 |
Topological Polar Surface Area: | 51.8 |
Undefined Atom Stereocenter Count: | 0 |
Undefined Bond Stereocenter Count: | 0 |
XLogP3: | 1.4 |
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