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| IUPAC Name: | N-(2-amino-4,6-dichloropyrimidin-5-yl)formamide |
| Description: | 2-Amino-4,6-dichloro-5-formamidopyrimidine (CAS# 171887-03-9) is an intermediate of Abacavir (A105000). Abacavir is a carbocyclic 2'-deoxyguanosine nucleoside reverse transcriptase inhibitor and an anti-HIV drug used to treat HIV infection (1). Intracellular enzymes convert Abacavir to its active form, carbovir-triphosphate (CBV-TP), which then selectively inhibits HIV reverse transcriptase by incorporating into viral DNA (2). Abacavir is metabolized in the liver by uridine diphosphate glucuronyltransferase and alcohol dehydrogenase resulting in inactive glucuronide and carboxylate metabolites, respectively. |
| Molecular Weight: | 207.02 |
| Molecular Formula: | C5H4Cl2N4O |
| Canonical SMILES: | C(=O)NC1=C(N=C(N=C1Cl)N)Cl |
| InChI: | InChI=1S/C5H4Cl2N4O/c6-3-2(9-1-12)4(7)11-5(8)10-3/h1H,(H,9,12)(H2,8,10,11) |
| InChI Key: | XYWHZUCZNRMJGO-UHFFFAOYSA-N |
| Boiling Point: | 554.8 °C at 760 mmHg |
| Density: | 1.742 g/cm3 |
| MDL: | MFCD04112936 |
| LogP: | 2.22400 |
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1-(2-Cyanoethyl)-3-methyl-6-phenyl-1H-pyrazolo[3,4-b]pyridine-4-carboxylic acid
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