2,6-Difluorophenol - CAS 28177-48-2

Catalog:	BB019786
Product Name:	2,6-Difluorophenol
CAS:	28177-48-2
Synonyms:	2,6-difluorophenol

Technical Data

Safety and Hazards

Patents

Literatures

Computed Properties

IUPAC Name:	2,6-difluorophenol
Description:	2,6-Difluorophenol (CAS# 28177-48-2) is a bioisosteric analog of γ-Aminobutyric Acid (GABA). It can also be used to prepare isoxazolone (I918120) based inhibitors of tumor necrosis factor-alpha (TNF-α).
Molecular Weight:	130.09
Molecular Formula:	C6H4F2O
Canonical SMILES:	C1=CC(=C(C(=C1)F)O)F
InChI:	InChI=1S/C6H4F2O/c7-4-2-1-3-5(8)6(4)9/h1-3,9H
InChI Key:	CKKOVFGIBXCEIJ-UHFFFAOYSA-N
Boiling Point:	59-61 °C (17 mmHg)
Purity:	98 %
Density:	1.27 g/cm³
Appearance:	Colorless crystalline low melting solid
MDL:	MFCD00002158
LogP:	1.67040

Publication Number	Title	Priority Date
CN-113354646-A	8-aryloxy alkoxy substituted xanthine derivative and preparation method and application thereof	20210706
CN-113150287-A	Preparation method of cross-linkable fluorine-containing polyphosphazene	20210421
CN-112479825-A	Synthetic method of compound containing fluorophenol structure	20201126
CN-112979424-A	Synthetic method of compound containing fluorophenol structure	20201126
CN-111530390-A	Continuous production device and method of 2, 4-difluoro-3-methoxybenzoic acid	20200512

PMID	Publication Date	Title	Journal
21800903	20110908	Hydrogen bonding effects on the wavenumbers and absorption intensities of the OH fundamental and the first, second, and third overtones of phenol and 2,6-dihalogenated phenols studied by visible/near-infrared/infrared spectroscopy	The journal of physical chemistry. A
21288726	20110215	Structure-activity relations on [1-(3,5-difluoro-4-hydroxyphenyl)-1H-pyrrol-3-yl]phenylmethanone. The effect of methoxy substitution on aldose reductase inhibitory activity and selectivity	Bioorganic & medicinal chemistry
20936791	20101111	A diverse series of substituted benzenesulfonamides as aldose reductase inhibitors with antioxidant activity: design, synthesis, and in vitro activity	Journal of medicinal chemistry
20803586	20100924	Modulation of the aerobic oxidative polymerization in phenylazomethine dendrimers assembling copper complexes	Chemistry (Weinheim an der Bergstrasse, Germany)
11421721	20010702	Tricyclohexylphosphine derivatives of bis(2,6-difluorophenoxide)cadmium: a solution and solid-state NMR study	Inorganic chemistry

Related Products

Online Inquiry

Name:

* Phone:

* Service & Products of Interested:

Project Description:

* Quantity:

* Email:

* Verification Code:

Customer Support

If the product you need is not in our catalog, please contact us in time to submit your needs. You can help our website get better and better. Why not submit the request today?

Submit Requirement

Customer Centered

Global Delivery

Warehouses in multiple cities to ensure fast delivery

Quality Assurance

Strict process parameter control to ensure product quality

Large Stock

> 20,000 building blocks and intermediates from stock

Process Scale-up

Process scale-up from lab to industrial scale

Flexible Batch Size

Flexible batch size for diverse industrial demands

Related Functional Groups

Fluorinated Building Blocks

[1946823-77-3]
[1,4-Dimethyl-3-(trifluoromethyl)-1H-pyrazol-5-yl]methanol
[1866059-82-6]
1,1,2,2-Tetrafluoro-3-methylsulfonylpropane
[2367-82-0]
1,2,3,5-Tetrafluorobenzene
[1011396-69-2]
2,2-Difluoro-N-(4-methoxy-3-(methoxymethyl)benzyl)ethanamine
[5310-68-9]
4-Chlorophenylsulphur pentafluoride
[1328640-88-5]
5-((2,2-Difluoroethoxy)methyl)-1-methyl-3-nitro-1H-pyrazole

Other Pyrimidines

[2367-82-0]
1,2,3,5-Tetrafluorobenzene
[1183749-69-0]
2-(pyrimidin-2-yloxy)phenol
[2696462-69-6]
4-(4-Aminopyrimidin-2-yl)-2-methyl-1-(2-trimethylsilylethoxymethyl)pyrazol-3-one
[451-46-7]
Ethyl 4-fluorobenzoate
[207605-39-8]
trans-2,3,4,5,6-Pentafluoro-β-nitrostyrene
[1489-53-8]
1,2,3-Trifluorobenzene

Oxygen Compounds

[77987-49-6]
Z-Glycinol
[5896-75-3]
(Z)-N-(4-Phenylpiperazin-1-yl)-1-(2,3,4-trimethoxyphenyl)methanimine
[1281984-38-0]
1-Cyclopentyl-3,5-dinitro-1H-pyrazole
[24550-39-8]
3-[(4-Chlorobenzyl)oxy]benzaldehyde
[832739-83-0]
3-[(4-Chlorophenyl)sulfonyl]-5-methoxyaniline
[862649-86-3]
3-[(4-Chlorophenyl)sulfonyl]-5-nitrophenol

GHS Hazard Statement:	H228 (97.87%): Flammable solid [Danger Flammable solids]
Precautionary Statement:	P210, P240, P241, P260, P261, P264, P270, P271, P280, P301+P312, P301+P330+P331, P302+P352, P303+P361+P353, P304+P340, P305+P351+P338, P310, P312, P321, P322, P330, P332+P313, P337+P313, P362, P363, P370+P378, P403+P233, P405, and P501
Signal Word:	Danger

Complexity:	87.1
Compound Is Canonicalized:	Yes
Covalently-Bonded Unit Count:	1
Defined Atom Stereocenter Count:	0
Defined Bond Stereocenter Count:	0
Exact Mass:	130.02302107
Formal Charge:	0
Heavy Atom Count:	9
Hydrogen Bond Acceptor Count:	3
Hydrogen Bond Donor Count:	1
Isotope Atom Count:	0
Monoisotopic Mass:	130.02302107
Rotatable Bond Count:	0
Topological Polar Surface Area:	20.2 Å²
Undefined Atom Stereocenter Count:	0
Undefined Bond Stereocenter Count:	0
XLogP3:	2