2-(4-Hydroxybutan-2-yl) O-Ethyl Dolutegravir

Catalog: BB064141
Product Name: 2-(4-Hydroxybutan-2-yl) O-Ethyl Dolutegravir
Synonyms: (R)-N-(2,4-Difluorobenzyl)-9-ethoxy-2-(4-hydroxybutan-2-yl)-1,8-dioxo-1,8-dihydro-2H-pyrido[1,2-a]pyrazine-7-carboxamide
Description:2-(4-Hydroxybutan-2-yl) O-Ethyl Dolutegravir is an impurity of Dolutegravir (D528800), which is a second generation HIV-1 integrase strand transfer inhibitor. Dolutegravir is currently in Phase III clinical trials for the treatment of HIV infection. Dolutegravir has been shown to potently inhibit HIV replication in cells such as peripheral blood mononuclear cells (PBMCs), MT-4 cells and CIP4 cells infected with a self-inactivating PHIV lentiviral vector.
Molecular Weight:447.44
Molecular Formula:C22H23F2N3O5
References:Kobayashi, M. et al. Antimicrob Agents Chemother., 55, 813 (2011); Garrido, C. et al. Antiviral, Res., 90, 164 (2011); Lenz, J.C.C. et al. Exp. Opin. Invest. Drugs, 20, 537 (2011).

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