2,4-Dichloro-6,7-dimethoxyquinazoline - CAS 27631-29-4
Catalog: |
BB019625 |
Product Name: |
2,4-Dichloro-6,7-dimethoxyquinazoline |
CAS: |
27631-29-4 |
Synonyms: |
2,4-dichloro-6,7-dimethoxyquinazoline |
IUPAC Name: | 2,4-dichloro-6,7-dimethoxyquinazoline |
Description: | 2,4-Dichloro-6,7-dimethoxyquinazoline (CAS# 27631-29-4) is an intermediate in the preparation of potential inhibitors of epidermal growth factor receptor kinases. An intermediate in the preparation of Terazosin (T105000). |
Molecular Weight: | 259.09 |
Molecular Formula: | C10H8Cl2N2O2 |
Canonical SMILES: | COC1=C(C=C2C(=C1)C(=NC(=N2)Cl)Cl)OC |
InChI: | InChI=1S/C10H8Cl2N2O2/c1-15-7-3-5-6(4-8(7)16-2)13-10(12)14-9(5)11/h3-4H,1-2H3 |
InChI Key: | DGHKCBSVAZXEPP-UHFFFAOYSA-N |
Boiling Point: | 340.5 °C at 760 mmHg |
Melting Point: | 172-177 °C |
Purity: | 95 % |
Density: | 1.424 g/cm3 |
Appearance: | Pale yellow to beige crystalline powder |
MDL: | MFCD00051733 |
LogP: | 2.95380 |
GHS Hazard Statement: | H315 (97.87%): Causes skin irritation [Warning Skin corrosion/irritation] |
Precautionary Statement: | P261, P264, P271, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P403+P233, P405, and P501 |
Signal Word: | Warning |
Publication Number | Title | Priority Date |
CN-113264889-A | Method suitable for industrial production and preparation of gefitinib | 20210611 |
CN-112480078-A | Quinazoline hydroxamic acid derivative and preparation method and application thereof | 20201110 |
JP-2021116291-A | A pharmaceutical composition containing a 2,4-diamino-6,7-dimethoxyquinazoline derivative as an active ingredient, and a 2,4-diamino-6,7-dimethoxyquinazoline derivative having a specific structure. | 20200124 |
CN-111138371-A | 2, 4-dichloro-6, 7-dimethoxyquinazoline solvate and preparation method thereof | 20191230 |
WO-2021132037-A1 | Curable composition, cured product, optical member and lens | 20191224 |
PMID | Publication Date | Title | Journal |
11703156 | 20011101 | Solid-phase synthesis of 2,4-diaminoquinazoline libraries | Journal of combinatorial chemistry |
Complexity: | 245 |
Compound Is Canonicalized: | Yes |
Covalently-Bonded Unit Count: | 1 |
Defined Atom Stereocenter Count: | 0 |
Defined Bond Stereocenter Count: | 0 |
Exact Mass: | 257.9962829 |
Formal Charge: | 0 |
Heavy Atom Count: | 16 |
Hydrogen Bond Acceptor Count: | 4 |
Hydrogen Bond Donor Count: | 0 |
Isotope Atom Count: | 0 |
Monoisotopic Mass: | 257.9962829 |
Rotatable Bond Count: | 2 |
Topological Polar Surface Area: | 44.2 Å2 |
Undefined Atom Stereocenter Count: | 0 |
Undefined Bond Stereocenter Count: | 0 |
XLogP3: | 3.4 |
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