2,3-Dibromomaleimide - CAS 1122-10-7

Catalog:	BB002901
Product Name:	2,3-Dibromomaleimide
CAS:	1122-10-7
Synonyms:	3,4-dibromo-1h-pyrrole-2,5-dione; 3,4-dibromo-2,5-dihydro-1H-pyrrole-2,5-dione

Technical Data

Safety and Hazards

Patents

Literatures

Computed Properties

IUPAC Name:	3,4-dibromopyrrole-2,5-dione
Description:	2,3-Dibromomaleimide is a marine derived natural product found in Axinella brevistyla.
Molecular Weight:	254.86
Molecular Formula:	C4HBr2NO2
Canonical SMILES:	C1(=C(C(=O)NC1=O)Br)Br
InChI:	InChI=1S/C4HBr2NO2/c5-1-2(6)4(9)7-3(1)8/h(H,7,8,9)
InChI Key:	BIKSKRPHKQWJCW-UHFFFAOYSA-N
Boiling Point:	275.3 °C at 760 mmHg
Melting Point:	228-231 °C
Purity:	95 %
Density:	2.661 g/cm³
Appearance:	Off white flakes, chips, powder
Storage:	Sealed in dry, Room Temperature
MDL:	MFCD00185696
LogP:	0.97300

Publication Number	Title	Priority Date
CN-113209019-A	Preparation method and application of NK cell co-stimulation polymer micelle	20210511
JP-2021066746-A	Conjugates of cytotoxic agents and cell-binding receptors	20210204
CN-112795943-A	Electrochemical synthesis method of 3, 4-dibromomaleimide	20201231
JP-2021073185-A	Its use in novel conjugates and specific conjugation of biomolecules with drugs	20201224
CN-113164621-A	Protein-drug conjugates and site-directed conjugation methods	20201208

PMID	Publication Date	Title	Journal
22809559	20120801	Synthesis and biological evaluation of analogs of the marine alkaloids granulatimide and isogranulatimide	European journal of medicinal chemistry
22188166	20120125	Polymeric dibromomaleimides as extremely efficient disulfide bridging bioconjugation and pegylation agents	Journal of the American Chemical Society
22095664	20120102	Bromomaleimide-linked bioconjugates are cleavable in mammalian cells	Chembiochem : a European journal of chemical biology
21271715	20110216	In situ maleimide bridging of disulfides and a new approach to protein PEGylation	Bioconjugate chemistry
20092331	20100217	Protein modification, bioconjugation, and disulfide bridging using bromomaleimides	Journal of the American Chemical Society

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Related Functional Groups

Carbonyl Compounds

[91125-43-8]
Sulfophenyl nonanoate sodium salt
[1427004-19-0]
DBCO-PEG4-NHS ester
[1018141-88-2]
1-(2-Cyanoethyl)-3-methyl-6-phenyl-1H-pyrazolo[3,4-b]pyridine-4-carboxylic acid
[1006443-01-1]
1-(5-Nitropyridin-2-yl)-1H-pyrazole-3-carboxylic acid
[253429-30-0]
1-Bromo-2-(2,2-diethoxyethoxy)-4-fluorobenzene
[91552-11-3]
2-(3-Chlorophenyl)cyclopropanecarboxylic Acid

GHS Hazard Statement:	H314 (100%): Causes severe skin burns and eye damage [Danger Skin corrosion/irritation]
Precautionary Statement:	P260, P261, P264, P272, P280, P301+P330+P331, P302+P352, P303+P361+P353, P304+P340, P305+P351+P338, P310, P321, P333+P313, P363, P405, and P501
Signal Word:	Danger

Complexity:	199
Compound Is Canonicalized:	Yes
Covalently-Bonded Unit Count:	1
Defined Atom Stereocenter Count:	0
Defined Bond Stereocenter Count:	0
Exact Mass:	254.83535
Formal Charge:	0
Heavy Atom Count:	9
Hydrogen Bond Acceptor Count:	2
Hydrogen Bond Donor Count:	1
Isotope Atom Count:	0
Monoisotopic Mass:	252.83740
Rotatable Bond Count:	0
Topological Polar Surface Area:	46.2 Å²
Undefined Atom Stereocenter Count:	0
Undefined Bond Stereocenter Count:	0
XLogP3:	1.1