2,3-Dibromomaleimide - CAS 1122-10-7
Catalog: |
BB002901 |
Product Name: |
2,3-Dibromomaleimide |
CAS: |
1122-10-7 |
Synonyms: |
3,4-dibromo-1h-pyrrole-2,5-dione; 3,4-dibromo-2,5-dihydro-1H-pyrrole-2,5-dione |
IUPAC Name: | 3,4-dibromopyrrole-2,5-dione |
Description: | 2,3-Dibromomaleimide is a marine derived natural product found in Axinella brevistyla. |
Molecular Weight: | 254.86 |
Molecular Formula: | C4HBr2NO2 |
Canonical SMILES: | C1(=C(C(=O)NC1=O)Br)Br |
InChI: | InChI=1S/C4HBr2NO2/c5-1-2(6)4(9)7-3(1)8/h(H,7,8,9) |
InChI Key: | BIKSKRPHKQWJCW-UHFFFAOYSA-N |
Boiling Point: | 275.3 °C at 760 mmHg |
Melting Point: | 228-231 °C |
Purity: | 95 % |
Density: | 2.661 g/cm3 |
Appearance: | Off white flakes, chips, powder |
Storage: | Sealed in dry, Room Temperature |
MDL: | MFCD00185696 |
LogP: | 0.97300 |
GHS Hazard Statement: | H314 (100%): Causes severe skin burns and eye damage [Danger Skin corrosion/irritation] |
Precautionary Statement: | P260, P261, P264, P272, P280, P301+P330+P331, P302+P352, P303+P361+P353, P304+P340, P305+P351+P338, P310, P321, P333+P313, P363, P405, and P501 |
Signal Word: | Danger |
Publication Number | Title | Priority Date |
CN-113209019-A | Preparation method and application of NK cell co-stimulation polymer micelle | 20210511 |
JP-2021066746-A | Conjugates of cytotoxic agents and cell-binding receptors | 20210204 |
CN-112795943-A | Electrochemical synthesis method of 3, 4-dibromomaleimide | 20201231 |
JP-2021073185-A | Its use in novel conjugates and specific conjugation of biomolecules with drugs | 20201224 |
CN-113164621-A | Protein-drug conjugates and site-directed conjugation methods | 20201208 |
PMID | Publication Date | Title | Journal |
22809559 | 20120801 | Synthesis and biological evaluation of analogs of the marine alkaloids granulatimide and isogranulatimide | European journal of medicinal chemistry |
22188166 | 20120125 | Polymeric dibromomaleimides as extremely efficient disulfide bridging bioconjugation and pegylation agents | Journal of the American Chemical Society |
22095664 | 20120102 | Bromomaleimide-linked bioconjugates are cleavable in mammalian cells | Chembiochem : a European journal of chemical biology |
21271715 | 20110216 | In situ maleimide bridging of disulfides and a new approach to protein PEGylation | Bioconjugate chemistry |
20092331 | 20100217 | Protein modification, bioconjugation, and disulfide bridging using bromomaleimides | Journal of the American Chemical Society |
Complexity: | 199 |
Compound Is Canonicalized: | Yes |
Covalently-Bonded Unit Count: | 1 |
Defined Atom Stereocenter Count: | 0 |
Defined Bond Stereocenter Count: | 0 |
Exact Mass: | 254.83535 |
Formal Charge: | 0 |
Heavy Atom Count: | 9 |
Hydrogen Bond Acceptor Count: | 2 |
Hydrogen Bond Donor Count: | 1 |
Isotope Atom Count: | 0 |
Monoisotopic Mass: | 252.83740 |
Rotatable Bond Count: | 0 |
Topological Polar Surface Area: | 46.2 Å2 |
Undefined Atom Stereocenter Count: | 0 |
Undefined Bond Stereocenter Count: | 0 |
XLogP3: | 1.1 |
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