2,3,5,6-Tetramethylpyrazine - CAS 1124-11-4

Catalog	Size	Price	Stock	Quantity
BB002961	20 mg	$199	In stock

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Technical Data

IUPAC Name:	2,3,5,6-tetramethylpyrazine
Description:	Tetramethylpyrazine could protect against CoCl2 -induced neurotoxicity in PC12 cells and in rats, as evidenced by enhancement of cell viability in PC12 cells and improvement of learning and memory ability in rats treated by CoCl2.
Molecular Weight:	136.19
Molecular Formula:	C8H12N2
Canonical SMILES:	CC1=C(N=C(C(=N1)C)C)C
InChI:	InChI=1S/C8H12N2/c1-5-6(2)10-8(4)7(3)9-5/h1-4H3
InChI Key:	FINHMKGKINIASC-UHFFFAOYSA-N
Boiling Point:	190 ℃
Melting Point:	82-86°C
Flash Point:	128-130℃/200mm
Purity:	> 98 %
Density:	1.08 g/cm³
Solubility:	Sealed in dry, Room Temperature
Appearance:	Powder
Storage:	Sealed in dry, Room Temperature
MDL:	MFCD00006146
LogP:	1.71020
Quality Standard:	CP2010
Refractive Index:	1.503
Stability:	Stable. Incompatible with strong acids, strong oxidizing agents.

GHS Hazard Statement:	H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]
Precautionary Statement:	P264, P270, P301+P312, P330, and P501
Signal Word:	Warning

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PMID	Publication Date	Title	Journal
32135237	20200601	Tetramethylpyrazine alleviates iron overload damage in vascular endothelium via upregulating DDAHII expression	Toxicology in vitro : an international journal published in association with BIBRA
30744607	20190211	Ligustrazin increases lung cell autophagy and ameliorates paraquat-induced pulmonary fibrosis by inhibiting PI3K/Akt/mTOR and hedgehog signalling via increasing miR-193a expression	BMC pulmonary medicine
28034800	20171101	Effects of tetramethylpyrazine from Chinese black vinegar on antioxidant and hypolipidemia activities in HepG2 cells	Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
27837167	20170201	Nrf2 Activation Is Required for Ligustrazine to Inhibit Hepatic Steatosis in Alcohol-Preferring Mice and Hepatocytes	Toxicological sciences : an official journal of the Society of Toxicology
26404762	20160901	2,3,5,6-Tetramethylpyrazine (TMP) down-regulated arsenic-induced heme oxygenase-1 and ARS2 expression by inhibiting Nrf2, NF-κB, AP-1 and MAPK pathways in human proximal tubular cells	Archives of toxicology

Complexity:	87.8
Compound Is Canonicalized:	Yes
Covalently-Bonded Unit Count:	1
Defined Atom Stereocenter Count:	0
Defined Bond Stereocenter Count:	0
Exact Mass:	136.100048391
Formal Charge:	0
Heavy Atom Count:	10
Hydrogen Bond Acceptor Count:	2
Hydrogen Bond Donor Count:	0
Isotope Atom Count:	0
Monoisotopic Mass:	136.100048391
Rotatable Bond Count:	0
Topological Polar Surface Area:	25.8 Å²
Undefined Atom Stereocenter Count:	0
Undefined Bond Stereocenter Count:	0
XLogP3:	1.3