2, 3, 4, 6- Tetrakis(2, 2- dimethylpropanoate) D-Glucono-1,5-lactone - CAS 157737-38-7

Catalog: BB057406
Product Name: 2, 3, 4, 6- Tetrakis(2, 2- dimethylpropanoate) D-Glucono-1,5-lactone
CAS: 157737-38-7
Synonyms: (3R,4S,5R,6R)-2-Oxo-6-((pivaloyloxy)methyl)tetrahydro-2H-pyran-3,4,5-triyl tris(2,2-dimethylpropanoate)
Description:2, 3, 4, 6- Tetrakis(2, 2- dimethylpropanoate) D-Glucono-1,5-lactone is an intermediate in the synthesis of Canagliflozin Dimer (C175225), a dimer impurity of Canagliflozin (C175190); a sodium/glucose cotransporter 2 (SGLT2) inhibitor. Canagliflozin has been shown to dose dependently reduce calculated renal threshold for glucose excretion and increase urinary glucose excretion. Canagliflozin is a candidate for the treatment of type 2 diabetes and obesity.
Molecular Weight:514.61
Molecular Formula:C26H42O10
References:Chao, E. et al. Drug Fut., 36, 351 (2011); Sha, S. et al. Diab. Obes. Metab., 13, 669 (2011); Kipnes, M.S. Clin. Invest., 1, 145 (2011).

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