Betahistine - CAS 5638-76-6
Catalog:
BB029346
Product Name:
Betahistine
CAS:
5638-76-6
Synonyms:
N-methyl-2-pyridin-2-ylethanamine
Application:
Betahistine is used in Meniere disease and in vascular headaches. It is an antivertigo drug first used for treating vertigo. It is also commonly used for patients with balance disorders.
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BB029346
2 g
$377
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Related CAS: 5579-84-0 (dihydrochloride) 54856-23-4 (mesylate)
IUPAC Name: N-methyl-2-pyridin-2-ylethanamine
Description: Betahistine is a H1 receptor agonist, which serves as a vasodilator. It is used in Meniere disease and in vascular headaches but may exacerbate bronchial asthma and peptic ulcers. It is an antivertigo drug first used for treating vertigo. It is also commonly used for patients with balance disorders. It is believed to act by reducing the asymmetrical functioning of sensory vestibular organs as well as by increasing vestibulocochlear blood flow. It also acts as a histamine H3-receptor antagonist which causes an increased output of histamine from histaminergic nerve endings which can further increase the direct H1-agonist activity. It has been listed.
Molecular Weight: 136.19
Molecular Formula: C8H12N2
Canonical SMILES: CNCCC1=CC=CC=N1
InChI: InChI=1S/C8H12N2/c1-9-7-5-8-4-2-3-6-10-8/h2-4,6,9H,5,7H2,1H3
InChI Key: UUQMNUMQCIQDMZ-UHFFFAOYSA-N
Boiling Point: 113-114 ℃
Melting Point: 148-149 ℃
Purity: 98 %
Density: 0.984 g/cm3
Solubility: Soluble in DMSO, not in water
Appearance: Colourless liquid
Storage: -20 ℃ Freezer
MDL: MFCD00006362
LogP: 1.23440
Quality Standard: In-house standard
GHS Hazard Statement: H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]
Precautionary Statement: P261, P264, P271, P280, P302+P352, P304+P340, P305+P351+P338, P312, P321, P332+P313, P337+P313, P362, P403+P233, P405, and P501
Signal Word: Warning
Publication Number Title Priority Date
CN-113288895-A Medicine for treating meniere disease and application thereof 20210621
CN-113082025-A Application of dihydroxybenzamide derivatives in preparation of SerC inhibitor and antituberculosis drug 20210414
CN-112691182-A Traditional Chinese medicine composition for treating cervical spondylosis and preparation method thereof 20210126
CN-112481226-A Alcohol dehydrogenase mutant and application thereof 20201127
RU-2755458-C1 Intranasal system for delivery of medicinal substances to the brain 20200924
PMID Publication Date Title Journal
28551711 20171201 Why are most phospholipidosis inducers also hERG blockers? Archives of toxicology
22624822 20121001 Histamine H4 receptor antagonists as potent modulators of mammalian vestibular primary neuron excitability British journal of pharmacology
21770719 20120901 Development of novel sustained release matrix pellets of betahistine dihydrochloride: effect of lipophilic surfactants and co-surfactants Pharmaceutical development and technology
22695490 20120901 Reducing olanzapine-induced weight gain side effect by using betahistine: a study in the rat model Journal of psychopharmacology (Oxford, England)
22513171 20120801 Synthesis and characterization of new chromium, molybdenum and tungsten complexes of 2-[2-(methylaminoethyl)] pyridine Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy
Complexity: 83.3
Compound Is Canonicalized: Yes
Covalently-Bonded Unit Count: 1
Defined Atom Stereocenter Count: 0
Defined Bond Stereocenter Count: 0
Exact Mass: 136.100048391
Formal Charge: 0
Heavy Atom Count: 10
Hydrogen Bond Acceptor Count: 2
Hydrogen Bond Donor Count: 1
Isotope Atom Count: 0
Monoisotopic Mass: 136.100048391
Rotatable Bond Count: 3
Topological Polar Surface Area: 24.9 Å2
Undefined Atom Stereocenter Count: 0
Undefined Bond Stereocenter Count: 0
XLogP3: 0.4
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Related Functional Groups
Pyridines
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