2-(2-(2-Aminoethoxy)ethoxy)acetic acid - CAS 134978-97-5
Catalog: |
BB008049 |
Product Name: |
2-(2-(2-Aminoethoxy)ethoxy)acetic acid |
CAS: |
134978-97-5 |
Synonyms: |
Amino-PEG2-CH2CO2H; Amino-PEG2-CH2COOH; Amino-PEG2-acetic acid |
Ordering Information
Catalog |
Size |
Price |
Stock |
BB008049 |
1 g |
$176 |
In stock |
IUPAC Name: | 2-[2-(2-aminoethoxy)ethoxy]acetic acid |
Description: | H2N-PEG2-CH2COOH belongs to a polyethylene glycol (PEG) linker covalently bound to E3 Ligase binding group (E3LB) and protein binding group (PB). H2N-PEG2-CH2COOH is a PEG derivative containing an amino group with a terminal carboxylic acid. The amino group is reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde) etc. The terminal carboxylic acid can be reacted with primary amine groups in the presence of activators (e.g. EDC, or DCC) to form a stable amide bond. PEG Linkers may be useful in the development of antibody drug conjugates and PROTACs. |
Molecular Weight: | 163.17 |
Molecular Formula: | C6H13NO4 |
Canonical SMILES: | C(COCCOCC(=O)O)N |
InChI: | InChI=1S/C6H13NO4/c7-1-2-10-3-4-11-5-6(8)9/h1-5,7H2,(H,8,9) |
InChI Key: | RUVRGYVESPRHSZ-UHFFFAOYSA-N |
Boiling Point: | 323.8 ℃ at 760 mmHg |
Purity: | ≥95% |
Density: | 1.177 g/cm3 |
Solubility: | Soluble in DMSO (10 mm) |
Appearance: | White Powder |
Storage: | Store at 2-8°C |
LogP: | -0.23680 |
GHS Hazard Statement: | H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral] |
Precautionary Statement: | P261, P264, P270, P271, P280, P301+P312, P302+P352, P304+P312, P304+P340, P312, P322, P330, P363, and P501 |
Signal Word: | Warning |
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PMID | Publication Date | Title | Journal |
22823539 | 20120821 | Three wavelength substrate system of neutrophil serine proteinases | Analytical chemistry |
22541299 | 20120601 | A general route to xyloglucan-peptide conjugates for the activation of cellulose surfaces | Carbohydrate research |
22484541 | 20120408 | Adenanthin targets peroxiredoxin I and II to induce differentiation of leukemic cells | Nature chemical biology |
21751011 | 20111201 | Suppression of neovascularization and experimental arthritis by D-form of anti-flt-1 peptide conjugated with mini-PEG(™) | Angiogenesis |
22099392 | 20111118 | DNA-nanostructure-assembly by sequential spotting | Journal of nanobiotechnology |
Complexity: | 107 |
Compound Is Canonicalized: | Yes |
Covalently-Bonded Unit Count: | 1 |
Defined Atom Stereocenter Count: | 0 |
Defined Bond Stereocenter Count: | 0 |
Exact Mass: | 163.08445790 |
Formal Charge: | 0 |
Heavy Atom Count: | 11 |
Hydrogen Bond Acceptor Count: | 5 |
Hydrogen Bond Donor Count: | 2 |
Isotope Atom Count: | 0 |
Monoisotopic Mass: | 163.08445790 |
Rotatable Bond Count: | 7 |
Topological Polar Surface Area: | 81.8 Å2 |
Undefined Atom Stereocenter Count: | 0 |
Undefined Bond Stereocenter Count: | 0 |
XLogP3: | -3.7 |
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Amines and Anilines
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