2-(2-(2-Aminoethoxy)ethoxy)acetic acid - CAS 134978-97-5
Catalog:
BB008049
Product Name:
2-(2-(2-Aminoethoxy)ethoxy)acetic acid
CAS:
134978-97-5
Synonyms:
Amino-PEG2-CH2CO2H; Amino-PEG2-CH2COOH; Amino-PEG2-acetic acid
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BB008049
1 g
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IUPAC Name: 2-[2-(2-aminoethoxy)ethoxy]acetic acid
Description: H2N-PEG2-CH2COOH belongs to a polyethylene glycol (PEG) linker covalently bound to E3 Ligase binding group (E3LB) and protein binding group (PB). H2N-PEG2-CH2COOH is a PEG derivative containing an amino group with a terminal carboxylic acid. The amino group is reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde) etc. The terminal carboxylic acid can be reacted with primary amine groups in the presence of activators (e.g. EDC, or DCC) to form a stable amide bond. PEG Linkers may be useful in the development of antibody drug conjugates and PROTACs.
Molecular Weight: 163.17
Molecular Formula: C6H13NO4
Canonical SMILES: C(COCCOCC(=O)O)N
InChI: InChI=1S/C6H13NO4/c7-1-2-10-3-4-11-5-6(8)9/h1-5,7H2,(H,8,9)
InChI Key: RUVRGYVESPRHSZ-UHFFFAOYSA-N
Boiling Point: 323.8 °C at 760 mmHg
Purity: ≥95%
Density: 1.177 g/cm3
Solubility: Soluble in DMSO (10 mm)
Appearance: White Powder
Storage: Store at 2-8°C
LogP: -0.23680
GHS Hazard Statement: H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]
Precautionary Statement: P261, P264, P270, P271, P280, P301+P312, P302+P352, P304+P312, P304+P340, P312, P322, P330, P363, and P501
Signal Word: Warning
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Complexity: 107
Compound Is Canonicalized: Yes
Covalently-Bonded Unit Count: 1
Defined Atom Stereocenter Count: 0
Defined Bond Stereocenter Count: 0
Exact Mass: 163.08445790
Formal Charge: 0
Heavy Atom Count: 11
Hydrogen Bond Acceptor Count: 5
Hydrogen Bond Donor Count: 2
Isotope Atom Count: 0
Monoisotopic Mass: 163.08445790
Rotatable Bond Count: 7
Topological Polar Surface Area: 81.8 Å2
Undefined Atom Stereocenter Count: 0
Undefined Bond Stereocenter Count: 0
XLogP3: -3.7
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Amines and Anilines
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