MPP+ iodide - CAS 36913-39-0
Catalog: |
BB023127 |
Product Name: |
MPP+ iodide |
CAS: |
36913-39-0 |
Synonyms: |
N-Methyl-4-Phenylpyridinium Iodide |
IUPAC Name: | 1-methyl-4-phenylpyridin-1-ium;iodide |
Description: | MPP+ iodide is the metabolite of a neurotoxin MPTP, which causes permanent symptoms of Parkinson's disease by killing certain neurons in the substantia nigra of the brain. |
Molecular Weight: | 297.13 |
Molecular Formula: | C12H12IN |
Canonical SMILES: | C[N+]1=CC=C(C=C1)C2=CC=CC=C2.[I-] |
InChI: | InChI=1S/C12H12N.HI/c1-13-9-7-12(8-10-13)11-5-3-2-4-6-11;/h2-10H,1H3;1H/q+1;/p-1 |
InChI Key: | RFDFRDXIIKROAI-UHFFFAOYSA-M |
LogP: | 3.74680 |
GHS Hazard Statement: | H301 (100%): Toxic if swallowed [Danger Acute toxicity, oral]; H311 (100%): Toxic in contact with skin [Danger Acute toxicity, dermal]; H315 (100%): Causes skin irritation [Warning Skin corrosion/irritation]; H319 (100%): Causes serious eye irritation [Warning Serious eye damage/eye irritation]; H331 (100%): Toxic if inhaled [Danger Acute toxicity, inhalation]; H335 (100%): May cause respiratory irritation [Warning Specific target organ toxicity, single exposure; Respiratory tract irritation] |
Precautionary Statement: | P261, P264, P264+P265, P270, P271, P280, P301+P316, P302+P352, P304+P340, P305+P351+P338, P316, P319, P321, P330, P332+P317, P337+P317, P361+P364, P362+P364, P403+P233, P405, and P501 |
Signal Word: | Danger |
Publication Number | Title | Priority Date |
EP-3792252-A1 | Thiazole and diphenyl substituted sulfoxides for use in improving cognition functions and against addictions to substances. | 20190913 |
KR-102029090-B1 | Composition for Preventing or Treating Parkinson's Disease Comprising O-Cyclic Phytosphingosine-1-phosphate | 20190711 |
WO-2021006663-A1 | Composition comprising o-cyclic phytosphingosine-1-phosphate for preventing or treating parkinson's disease | 20190711 |
WO-2020125462-A1 | Use of composition comprising ferrous amino acid chelate particles in the preparation of medicament for treating or relieving diseases associated with nerve damage | 20181220 |
TW-202034908-A | Use of a composition containing ferroamino acid chelate particles for preparing medicines for treating or slowing down nerve damage related diseases | 20181220 |
PMID | Publication Date | Title | Journal |
28770951 | 20170701 | MicroRNA-181c functions as a protective factor in a 1-methyl-4-phenylpyridinium iodide-induced cellular Parkinson's disease model via BCL2L11 | European review for medical and pharmacological sciences |
27366949 | 20160719 | Delta-9-tetrahydrocannabinol protects against MPP+ toxicity in SH-SY5Y cells by restoring proteins involved in mitochondrial biogenesis | Oncotarget |
23003105 | 20121105 | Transporter targeted gatifloxacin prodrugs: synthesis, permeability, and topical ocular delivery | Molecular pharmaceutics |
22265823 | 20120301 | Involvement of activation of PI3K/Akt pathway in the protective effects of puerarin against MPP+-induced human neuroblastoma SH-SY5Y cell death | Neurochemistry international |
21972102 | 20120101 | Standardized extracts of Bacopa monniera protect against MPP+- and paraquat-induced toxicity by modulating mitochondrial activities, proteasomal functions, and redox pathways | Toxicological sciences : an official journal of the Society of Toxicology |
Complexity: | 141 |
Compound Is Canonicalized: | Yes |
Covalently-Bonded Unit Count: | 2 |
Defined Atom Stereocenter Count: | 0 |
Defined Bond Stereocenter Count: | 0 |
Exact Mass: | 297.00145 |
Formal Charge: | 0 |
Heavy Atom Count: | 14 |
Hydrogen Bond Acceptor Count: | 1 |
Hydrogen Bond Donor Count: | 0 |
Isotope Atom Count: | 0 |
Monoisotopic Mass: | 297.00145 |
Rotatable Bond Count: | 1 |
Topological Polar Surface Area: | 3.9 |
Undefined Atom Stereocenter Count: | 0 |
Undefined Bond Stereocenter Count: | 0 |
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