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| Description: | 2,2,6,6-Tetramethylpiperidine-1,4-diol is related to 4-Hydroxy-2,2,6,6-tetramethyl-1-piperidinyloxy (H956500), which is a free radical scavenger. 2,2,6,6-Tetramethylpiperidine-1,4-diol has also been shown to be an in vitro and in vivo radioprotector. It is used as a reagent in stereoselective preparation of tetrasubstituted triarylated olefins via Pd-catalyzed sequential oxidative Heck arylation of alkenes with arylboronic acids using nitroxides as oxidants. |
| Molecular Weight: | 209.71 |
| Molecular Formula: | C9H20ClNO2 |
| Melting Point: | >208°C (dec.) |
| Solubility: | DMSO (Slightly), Methanol (Slightly) |
| Appearance: | White to Off-White Solid |
| Storage: | Hygroscopic, -20°C Freezer, Under inert atmosphere |
| References: | Flather, M., et al. Lancet, 355, 1575 (2000); Sasso, F., et al. Metabolism, 52, 675 (2003); Kass, D., et al. Circ. Res., 94, 1533 (2004); Murdoch, C., et al. Cardiovasc Res., 71, 208 (2006); Hahn, M., et al. Free Radic. Biol. Med., 28, 953 (2000); He, Z., et al. Angew. Chem. Int. Ed., 51, 3699 (2012). |
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