1-N-Boc-3-hydroxyazetidine - CAS 141699-55-0
Catalog: |
BB009216 |
Product Name: |
1-N-Boc-3-hydroxyazetidine |
CAS: |
141699-55-0 |
Synonyms: |
1-Boc-3-hydroxyazetidine; N-Boc-3-hydroxyazetidine; 1-(tert-Butoxycarbonyl)-3-hydroxyazetidine; 3-Hydroxy-azetidine-1-carboxylic acid tert-butyl ester |
IUPAC Name: | tert-butyl 3-hydroxyazetidine-1-carboxylate |
Description: | 1-N-Boc-3-hydroxyazetidine is a non-cleavable ADC linker and also an alkyl chain-based PROTAC linker. |
Molecular Weight: | 173.21 |
Molecular Formula: | C8H15NO3 |
Canonical SMILES: | CC(C)(C)OC(=O)N1CC(C1)O |
InChI: | InChI=1S/C8H15NO3/c1-8(2,3)12-7(11)9-4-6(10)5-9/h6,10H,4-5H2,1-3H3 |
InChI Key: | XRRXRQJQQKMFBC-UHFFFAOYSA-N |
Boiling Point: | 253.7±33.0 °C at 760 mmHg |
Melting Point: | 36-43°C |
Density: | 1.184±0.06 g/cm3 |
Storage: | Keep in dark place, Sealed in dry, Room Temperature |
MDL: | MFCD04115305 |
LogP: | 0.53590 |
GHS Hazard Statement: | H302 (81.63%): Harmful if swallowed [Warning Acute toxicity, oral] |
Precautionary Statement: | P261, P264, P270, P271, P280, P301+P312, P302+P352, P304+P340, P305+P351+P338, P310, P312, P321, P330, P332+P313, P337+P313, P362, P403+P233, P405, and P501 |
Signal Word: | Danger |
Publication Number | Title | Priority Date |
CN-111362853-A | Preparation method of 3-oxazetidine-1-carboxylic acid tert-butyl ester | 20200427 |
CN-113509557-A | Targeted protease degradation platform (TED) | 20200409 |
WO-2021205391-A1 | Targeted protease degradation (ted) platform | 20200409 |
WO-2021207172-A1 | Compounds and methods for targeted degradation of kras | 20200406 |
US-2021315896-A1 | Indazole based compounds and associated methods of use | 20200321 |
Complexity: | 179 |
Compound Is Canonicalized: | Yes |
Covalently-Bonded Unit Count: | 1 |
Defined Atom Stereocenter Count: | 0 |
Defined Bond Stereocenter Count: | 0 |
Exact Mass: | 173.10519334 |
Formal Charge: | 0 |
Heavy Atom Count: | 12 |
Hydrogen Bond Acceptor Count: | 3 |
Hydrogen Bond Donor Count: | 1 |
Isotope Atom Count: | 0 |
Monoisotopic Mass: | 173.10519334 |
Rotatable Bond Count: | 2 |
Topological Polar Surface Area: | 49.8 Å2 |
Undefined Atom Stereocenter Count: | 0 |
Undefined Bond Stereocenter Count: | 0 |
XLogP3: | 0.3 |
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