1-Boc-3-fluoro-4-hydroxypiperidine - CAS 373604-28-5
Catalog: |
BB023262 |
Product Name: |
1-Boc-3-fluoro-4-hydroxypiperidine |
CAS: |
373604-28-5 |
Synonyms: |
3-fluoro-4-hydroxy-1-piperidinecarboxylic acid tert-butyl ester; tert-butyl 3-fluoro-4-hydroxypiperidine-1-carboxylate |
IUPAC Name: | tert-butyl 3-fluoro-4-hydroxypiperidine-1-carboxylate |
Description: | 1-Boc-3-fluoro-4-hydroxypiperidine (CAS# 373604-28-5) is used in the preparation of therapeutic GPR 119 modulators. |
Molecular Weight: | 219.25 |
Molecular Formula: | C10H18FNO3 |
Canonical SMILES: | CC(C)(C)OC(=O)N1CCC(C(C1)F)O |
InChI: | InChI=1S/C10H18FNO3/c1-10(2,3)15-9(14)12-5-4-8(13)7(11)6-12/h7-8,13H,4-6H2,1-3H3 |
InChI Key: | XRNLYXKYODGLMI-UHFFFAOYSA-N |
Boiling Point: | 300.795 °C at 760 mmHg |
Density: | 1.156 g/cm3 |
Appearance: | White to yellow solid |
MDL: | MFCD11977352 |
LogP: | 1.26410 |
GHS Hazard Statement: | H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral] |
Precautionary Statement: | P261, P264, P270, P271, P280, P301+P312, P302+P352, P304+P312, P304+P340, P305+P351+P338, P312, P321, P322, P330, P332+P313, P337+P313, P362, P363, P403+P233, P405, and P501 |
Signal Word: | Warning |
Publication Number | Title | Priority Date |
WO-2020239103-A1 | Btk inhibitor ring derivative, preparation method therefor and pharmaceutical application thereof | 20190531 |
US-2020206201-A1 | Cereblon modulators and uses thereof | 20181228 |
US-2020216507-A1 | In vivo engineered cereblon protein | 20181228 |
US-10781239-B2 | In vivo engineered cereblon protein | 20181228 |
US-10869860-B2 | Cereblon modulators and uses thereof | 20181228 |
Complexity: | 239 |
Compound Is Canonicalized: | Yes |
Covalently-Bonded Unit Count: | 1 |
Defined Atom Stereocenter Count: | 0 |
Defined Bond Stereocenter Count: | 0 |
Exact Mass: | 219.12707160 |
Formal Charge: | 0 |
Heavy Atom Count: | 15 |
Hydrogen Bond Acceptor Count: | 4 |
Hydrogen Bond Donor Count: | 1 |
Isotope Atom Count: | 0 |
Monoisotopic Mass: | 219.12707160 |
Rotatable Bond Count: | 2 |
Topological Polar Surface Area: | 49.8 Å2 |
Undefined Atom Stereocenter Count: | 2 |
Undefined Bond Stereocenter Count: | 0 |
XLogP3: | 1 |
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