Amino-PEG4-propionic acid - CAS 663921-15-1

Name: Amino-PEG4-propionic acid
Brand: BOC Sciences
Rating: 5 (1 reviews)

Catalog:	BB033019
Product Name:	Amino-PEG4-propionic acid
CAS:	663921-15-1
Synonyms:	1-Amino-3,6,9,12-tetraoxapentadecan-15-oic acid; Amino-PEG4-acid; (PEO)4-amino-propionic acid

Technical Data

Related CAS:	1818294-41-5 (polymer) 196936-04-6 (polymer)
IUPAC Name:	3-[2-[2-[2-(2-aminoethoxy)ethoxy]ethoxy]ethoxy]propanoic acid
Description:	NH2-PEG4-CH2CH2COOH is a cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
Molecular Weight:	265.30
Molecular Formula:	C11H23NO6
Canonical SMILES:	C(COCCOCCOCCOCCN)C(=O)O
InChI:	InChI=1S/C11H23NO6/c12-2-4-16-6-8-18-10-9-17-7-5-15-3-1-11(13)14/h1-10,12H2,(H,13,14)
InChI Key:	DKUZHSDZSMQOGQ-UHFFFAOYSA-N
Boiling Point:	409.6±40.0 °C at 760 mmHg
Flash Point:	201.5±27.3 °C
Purity:	> 98.0 %
Density:	1.1±0.1 g/cm3
Solubility:	10 mm in DMSO
Appearance:	Solid
Storage:	-20 °C
LogP:	-1.92
Vapor Pressure:	0.0±2.1 mmHg at 25°C

GHS Hazard Statement:	H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]
Precautionary Statement:	P261, P264, P270, P271, P280, P301+P312, P302+P352, P304+P312, P304+P340, P305+P351+P338, P312, P321, P322, P330, P332+P313, P337+P313, P362, P363, P403+P233, P405, and P501
Signal Word:	Warning

Publication Number	Title	Priority Date
WO-2021167107-A1	Human transferrin receptor binding peptide	20200222
US-2021139548-A1	Npy2 receptor agonists	20191111
WO-2021094259-A1	Npy2 receptor agonists	20191111
WO-2020254197-A1	Adrenomedullin-analogues for long-term stabilization and their use	20190618
WO-2020256545-A1	Agents for cleaving labels from biomolecules in vivo	20190617

PMID	Publication Date	Title	Journal
20052508	20111101	Impact of bifunctional chelators on biological properties of 111In-labeled cyclic peptide RGD dimers	Amino acids
21521559	20111001	99mTc-labeled cyclic RGD peptides for noninvasive monitoring of tumor integrin αVβ3 expression	Molecular imaging
21780818	20110817	Evaluation of 99mTc-labeled cyclic RGD peptide with a PEG4 linker for thrombosis imaging: comparison with DMP444	Bioconjugate chemistry
21547153	20110118	Radiolabeled Cyclic RGD Peptides as Radiotracers for Imaging Tumors and Thrombosis by SPECT	Theranostics
21850213	20110101	Evaluation of In-Labeled Cyclic RGD Peptides: Effects of Peptide and Linker Multiplicity on Their Tumor Uptake, Excretion Kinetics and Metabolic Stability	Theranostics

Complexity:	190
Compound Is Canonicalized:	Yes
Covalently-Bonded Unit Count:	1
Defined Atom Stereocenter Count:	0
Defined Bond Stereocenter Count:	0
Exact Mass:	265.15253745
Formal Charge:	0
Heavy Atom Count:	18
Hydrogen Bond Acceptor Count:	7
Hydrogen Bond Donor Count:	2
Isotope Atom Count:	0
Monoisotopic Mass:	265.15253745
Rotatable Bond Count:	14
Topological Polar Surface Area:	100 Å²
Undefined Atom Stereocenter Count:	0
Undefined Bond Stereocenter Count:	0
XLogP3:	-4.1