1-(2-Methoxyphenyl)piperazine - CAS 35386-24-4
Catalog: |
BB022627 |
Product Name: |
1-(2-Methoxyphenyl)piperazine |
CAS: |
35386-24-4 |
Synonyms: |
1-(2-methoxyphenyl)piperazine |
IUPAC Name: | 1-(2-methoxyphenyl)piperazine |
Description: | A piperazine derivative and a selective antagonist at D3 receptors that influences the expression of cocaine-induced conditioned place preference (CPP). |
Molecular Weight: | 192.26 |
Molecular Formula: | C11H16N2O |
Canonical SMILES: | COC1=CC=CC=C1N2CCNCC2 |
InChI: | InChI=1S/C11H16N2O/c1-14-11-5-3-2-4-10(11)13-8-6-12-7-9-13/h2-5,12H,6-9H2,1H3 |
InChI Key: | VNZLQLYBRIOLFZ-UHFFFAOYSA-N |
Boiling Point: | 130-133 °C (0.1 mmHg) |
Melting Point: | 35-38 °C |
Purity: | 95 % |
Density: | 1.095 g/cm3 |
Appearance: | Off-white solid or liquid |
Storage: | Store in a tightly closed container. Store in a cool, dry, well-ventilated area away from incompatible substances. Store protected from moisture. |
MDL: | MFCD00005958 |
LogP: | 1.49860 |
GHS Hazard Statement: | H314 (97.92%): Causes severe skin burns and eye damage [Danger Skin corrosion/irritation] |
Precautionary Statement: | P260, P264, P280, P301+P330+P331, P303+P361+P353, P304+P340, P305+P351+P338, P310, P321, P363, P405, and P501 |
Signal Word: | Danger |
Publication Number | Title | Priority Date |
CN-112608275-A | Application of 2, 8-bis (trifluoromethyl) -4-hydroxyquinoline derivative in preparation and prevention and treatment of agricultural diseases | 20201229 |
CN-112010822-A | Method for preparing chiral gamma-amino alcohol and chiral alpha-allyl alcohol by one-pot method | 20200813 |
CN-111879767-A | Color development test method of piperazine novel mental active substance | 20200729 |
CN-111795963-A | Method for chromogenic detection of piperazine novel psychotropic active substances | 20200729 |
WO-2021194326-A1 | Aminopyrimidine derivatives and their use as aryl hydrocarbon receptor modulators | 20200327 |
PMID | Publication Date | Title | Journal |
26344803 | 20151201 | Structure-dependent inhibition of the human α1β2γ2 GABAA receptor by piperazine derivatives: A novel mode of action | Neurotoxicology |
22632094 | 20120809 | Molecular determinants of selectivity and efficacy at the dopamine D3 receptor | Journal of medicinal chemistry |
22809299 | 20120809 | A straightforward approach for engineering efficacy and selectivity at GPCRs | Journal of medicinal chemistry |
22738316 | 20120726 | Investigations on the 1-(2-biphenyl)piperazine motif: identification of new potent and selective ligands for the serotonin(7) (5-HT(7)) receptor with agonist or antagonist action in vitro or ex vivo | Journal of medicinal chemistry |
22464790 | 20120601 | Synthesis, characterization and biological evaluation of novel neutral fac-M(CO)3(SNO) complexes (M=Re, 99mTc) bearing the o-methoxyphenylpiperazine moiety | Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine |
Complexity: | 169 |
Compound Is Canonicalized: | Yes |
Covalently-Bonded Unit Count: | 1 |
Defined Atom Stereocenter Count: | 0 |
Defined Bond Stereocenter Count: | 0 |
Exact Mass: | 192.126263138 |
Formal Charge: | 0 |
Heavy Atom Count: | 14 |
Hydrogen Bond Acceptor Count: | 3 |
Hydrogen Bond Donor Count: | 1 |
Isotope Atom Count: | 0 |
Monoisotopic Mass: | 192.126263138 |
Rotatable Bond Count: | 2 |
Topological Polar Surface Area: | 24.5 Å2 |
Undefined Atom Stereocenter Count: | 0 |
Undefined Bond Stereocenter Count: | 0 |
XLogP3: | 1.4 |
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