1,2,3,4-Tetrahydro-2,6-naphthyridine Dihydrochloride - CAS 449175-43-3

Name: 1,2,3,4-Tetrahydro-2,6-naphthyridine Dihydrochloride
Brand: BOC Sciences
Rating: 5 (1 reviews)

Catalog:	BB057528
Product Name:	1,2,3,4-Tetrahydro-2,6-naphthyridine Dihydrochloride
CAS:	449175-43-3
Synonyms:	1,2,3,4-Tetrahydro-2,6-naphthyridine dihydrochloride; 1,2,3,4-Tetrahydro-[2,6]naphthyridine dihydrochloride; 1,2,3,4-tetrahydro-2,6-naphthyridine; dihydrochloride

Technical Data

IUPAC Name:	1,2,3,4-tetrahydro-2,6-naphthyridinedihydrochloride
Description:	1,2,3,4-Tetrahydro-2,6-naphthyridine Dihydrochloride is a salt analog of 1,2,3,4-Tetrahydro-2,6-naphthyridine (CAT# T295698), which is used in the synthetic preparation of quinolizidinone carboxylic acid selective M1 allosteric modulators. It may be useful in the preparation of isoquinolinylphenyloxazolidinone antibacterials and in the preparation of cyclohexanedicarboxamides as cathepsin inhibitors.
Molecular Weight:	134.18 + 2(36.46)
Molecular Formula:	C8H10N2·2(HCl)
Canonical SMILES:	C1CNCC2=C1C=NC=C2.Cl.Cl
InChI:	InChI=1S/C8H10N2.2ClH/c1-3-9-6-8-2-4-10-5-7(1)8/h1,3,6,10H,2,4-5H22*1H
InChI Key:	HXPFQYFUMUHIAT-UHFFFAOYSA-N
References:	Kuduk, S. D., et al. Bioorganic Med. Chem. Lett., 21, 1710 (2011); Paget, S. D., et al. PCT Int. Appl., 49 pp. (2002); Dossetter, A. G., et al. PCT Int. Appl., 66 pp. (2008).

GHS Hazard Statement:	H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral]
Precautionary Statement:	P261, P264, P264+P265, P270, P271, P280, P301+P317, P302+P352, P304+P340, P305+P351+P338, P319, P321, P330, P332+P317, P337+P317, P362+P364, P403+P233, P405, and P501
Signal Word:	Warning

Publication Number	Title	Priority Date
AU-2011304666-A1	Substituted benzamide compounds	20100922
CA-2811796-A1	Substituted benzamide compounds	20100922
EP-2619178-A1	Substituted benzamide compounds	20100922
JP-2013540750-A	Substituted benzamide compounds	20100922
KR-20140000682-A	Substituted Benzamide Compounds	20100922
US-2012071461-A1	Substituted Benzamide Compounds	20100922
US-8680159-B2	Bradykinin 1 receptor modulating compounds	20100922
WO-2012038081-A1	Substituted benzamide compounds	20100922
WO-2009001128-A1	1,2-cycl0hexane dicarboxamides as cathepsin inhibitors	20070626

Complexity:	114
Compound Is Canonicalized:	Yes
Covalently-Bonded Unit Count:	3
Defined Atom Stereocenter Count:	0
Defined Bond Stereocenter Count:	0
Exact Mass:	206.0377538
Formal Charge:	0
Heavy Atom Count:	12
Hydrogen Bond Acceptor Count:	2
Hydrogen Bond Donor Count:	3
Isotope Atom Count:	0
Monoisotopic Mass:	206.0377538
Rotatable Bond Count:	0
Topological Polar Surface Area:	24.9Å²
Undefined Atom Stereocenter Count:	0
Undefined Bond Stereocenter Count:	0