1,1-Dimethylbiguanide hydrochloride - CAS 1115-70-4

Catalog:	BB002779
Product Name:	1,1-Dimethylbiguanide hydrochloride
CAS:	1115-70-4
Synonyms:	Imidodicarbonimidic diamide, N,N-dimethyl-, hydrochloride (1:1); Biguanide, 1,1-dimethyl-, hydrochloride; Biguanide, 1,1-dimethyl-, monohydrochloride; Imidodicarbonimidic diamide, N,N-dimethyl-, monohydrochloride; Apo-Metformin; Apophage; Benofomin; Brot; Dabex; Denkaform; Fornidd; Geamet; Glifage; LA 6023; Meguan; Metformin hydrochloride; N,N-Dimethylbiguanide hydrochloride; N1,N1-Dimethylbiguanide hydrochloride; Nelbis; Neodipa; Obimat-SR; Orabet; Riomet; Siamformet; Walaphage
Application:	Hypoglycemic agents

Catalog	Size	Price	Stock	Quantity
BB002779	500 g	$199	In stock

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Technical Data

Related CAS:	15537-72-1 (Deleted CAS) 56258-19-6 (Deleted CAS) 144377-16-2 (Deleted CAS) 657-24-9 (free base)
IUPAC Name:	3-(diaminomethylidene)-1,1-dimethylguanidine;hydrochloride
Description:	1,1-Dimethylbiguanide hydrochloride is the hydrochloride salt of the biguanide metformin with antihyperglycemic and potential antineoplastic activities. It decreases hyperglycemia primarily by suppressing glucose production by the liver (hepatic gluconeogenesis).
Molecular Weight:	165.62
Molecular Formula:	C4H12ClN5
Canonical SMILES:	CN(C)C(=N)N=C(N)N.Cl
InChI:	InChI=1S/C4H11N5.ClH/c1-9(2)4(7)8-3(5)6;/h1-2H3,(H5,5,6,7,8);1H
InChI Key:	OETHQSJEHLVLGH-UHFFFAOYSA-N
Boiling Point:	224.1±50.0°C at 760 mmHg
Melting Point:	232°C
Purity:	≥95%
Solubility:	Soluble in DMSO (Slightly), Methanol (Slightly)
Appearance:	White crystalline powder
Storage:	Store at -20°C
Decomposition:	Hazardous decomposition products formed under fire conditions - carbon oxides, Nitrogen oxides (nox), Hydrogen chloride gas. /metformin hydrochloride/
MDL:	MFCD00012582
LogP:	1.05850
Quality Standard:	BP\EP\USP
Stability:	Stable under recommended storage conditions. /metformin hydrochloride/
Vapor Pressure:	7.58X10-5 mm Hg at 25 °C (est)

GHS Hazard Statement:	H302 (99.62%): Harmful if swallowed [Warning Acute toxicity, oral]
Precautionary Statement:	P261, P264, P270, P271, P273, P280, P301+P312, P302+P352, P304+P340, P305+P351+P338, P312, P321, P330, P332+P313, P337+P313, P362, P403+P233, P405, and P501
Signal Word:	Warning

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PMID	Publication Date	Title	Journal
34058177	20210825	Metformin impairs bile acid homeostasis in ethinylestradiol-induced cholestasis in mice	Chemico-biological interactions
33844015	20210716	Perfluorooctanesulfonic Acid (PFOS) Thwarts the Beneficial Effects of Calorie Restriction and Metformin	Toxicological sciences : an official journal of the Society of Toxicology
33823243	20210601	Vanillin exerts therapeutic effects against hyperglycemia-altered glucose metabolism and purinergic activities in testicular tissues of diabetic rats	Reproductive toxicology (Elmsford, N.Y.)
33147367	20210301	Cytotoxicity of metformin against HT29 colon cancer cells contributes to mitochondrial Sirt3 upregulation	Journal of biochemical and molecular toxicology
33476677	20210301	Metformin relieves H/R-induced cardiomyocyte injury through miR-19a/ACSL axis - possible therapeutic target for myocardial I/R injury	Toxicology and applied pharmacology

Complexity:	132
Compound Is Canonicalized:	Yes
Covalently-Bonded Unit Count:	2
Defined Atom Stereocenter Count:	0
Defined Bond Stereocenter Count:	0
Exact Mass:	165.0781231
Formal Charge:	0
Heavy Atom Count:	10
Hydrogen Bond Acceptor Count:	1
Hydrogen Bond Donor Count:	4
Isotope Atom Count:	0
Monoisotopic Mass:	165.0781231
Rotatable Bond Count:	2
Topological Polar Surface Area:	91.5 Å²
Undefined Atom Stereocenter Count:	0
Undefined Bond Stereocenter Count:	0