Rimantadine hydrochloride - CAS 1501-84-4
Catalog: |
BB010496 |
Product Name: |
Rimantadine hydrochloride |
CAS: |
1501-84-4 |
Synonyms: |
1-(1-adamantyl)ethanamine;hydrochloride |
Application: |
Used as an antiviral agent. |
Related CAS: | 13392-28-4
|
IUPAC Name: | 1-(1-adamantyl)ethanamine;hydrochloride |
Description: | Rimantadine hydrochloride, also called as Flumadine, is a nucleic acid synthesis inhibitor and an anti-influenza virus drug. |
Molecular Weight: | 215.76 |
Molecular Formula: | C12H21N · HCl |
Canonical SMILES: | CC(C12CC3CC(C1)CC(C3)C2)N.Cl |
InChI: | InChI=1S/C12H21N.ClH/c1-8(13)12-5-9-2-10(6-12)4-11(3-9)7-12;/h8-11H,2-7,13H2,1H3;1H |
InChI Key: | OZBDFBJXRJWNAV-UHFFFAOYSA-N |
Boiling Point: | 247.8 ℃ at 760 mmHg |
Melting Point: | 373-375 ℃ |
Flash Point: | 99.3ºC |
Purity: | > 98.0 % (N) |
Solubility: | Soluble to ≥ 2.5 mg/mL in DMSO |
Appearance: | White crystalline solid |
Storage: | Store in a cool and dry place and at 0 - 4 ℃ for short term (days to weeks) or -42 ℃ for long term (months to years). |
MDL: | MFCD00072023 |
LogP: | 4.05230 |
Vapor Pressure: | 0.0251mmHg at 25°C |
GHS Hazard Statement: | H302 (100%): Harmful if swallowed [Warning Acute toxicity, oral] |
Precautionary Statement: | P261, P264, P270, P271, P280, P301+P312, P302+P352, P304+P340, P305+P351+P338, P312, P321, P330, P332+P313, P337+P313, P362, P403+P233, P405, and P501 |
Signal Word: | Warning |
Publication Number | Title | Priority Date |
CN-112852823-A | Aptamer with capability of identifying acyclovir analogues in broad spectrum | 20210202 |
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CN-112409218-A | Neuraminidase inhibitor containing hydrazide structural fragment and medical application thereof | 20201201 |
CN-112326813-A | LC-MS/MS (liquid chromatography-mass spectrometry/mass spectrometry) determination method for residual amount of rimantadine in eggs | 20200929 |
CN-112076174-A | Rimantadine hydrochloride tablet and preparation method thereof | 20200904 |
PMID | Publication Date | Title | Journal |
22959366 | 20121201 | Determination of amantadine and rimantadine using a sensitive fluorescent probe | Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy |
21960669 | 20120901 | Absence of pharmacokinetic interaction between intravenous peramivir and oral oseltamivir or rimantadine in humans | Journal of clinical pharmacology |
22039289 | 20120801 | Pharmacokinetics and safety of coadministered oseltamivir and rimantadine in healthy volunteers: an open-label, multiple-dose, randomized, crossover study | Journal of clinical pharmacology |
22617756 | 20120801 | Prophylactic and therapeutic combination effects of rimantadine and oseltamivir against influenza virus A (H3N2) infection in mice | Antiviral research |
22816091 | 20120601 | New adamantane derivatives can overcome resistance of influenza A(H1N1)pdm2009 and A(H3N2) viruses to remantadine | Bulletin of experimental biology and medicine |
Complexity: | 180 |
Compound Is Canonicalized: | Yes |
Covalently-Bonded Unit Count: | 2 |
Defined Atom Stereocenter Count: | 0 |
Defined Bond Stereocenter Count: | 0 |
Exact Mass: | 215.1440774 |
Formal Charge: | 0 |
Heavy Atom Count: | 14 |
Hydrogen Bond Acceptor Count: | 1 |
Hydrogen Bond Donor Count: | 2 |
Isotope Atom Count: | 0 |
Monoisotopic Mass: | 215.1440774 |
Rotatable Bond Count: | 1 |
Topological Polar Surface Area: | 26 Å2 |
Undefined Atom Stereocenter Count: | 1 |
Undefined Bond Stereocenter Count: | 0 |
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Amines and Anilines
Nitrogen Compounds
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